ÐÓ°ÉÔ­´´

21/05/2025

The rise and rise of proteostasis

This feature was written by Becky Allen for the 2023-2024 ÐÓ°ÉÔ­´´ Review.

Proteostasis, the myriad mechanisms that ensure our proteins work correctly, is key to healthy ageing. We speak to Dr Della David and Dr Rahul Samant about their cutting-edge research, why proteostasis is such a growing area of strength at the ÐÓ°ÉÔ­´´, and how the new UK Proteostasis Network will help accelerate research in the field.

20/05/2025

Adapting to change and challenge

This feature was written by Becky Allen for the 2023-2024 ÐÓ°ÉÔ­´´ Review.

Understanding how things work underpins the ÐÓ°ÉÔ­´´â€™s past, present and future. Dr Simon Cook, ÐÓ°ÉÔ­´´ Director and head of the Signalling programme, explains why he’s an evangelist for discovery research, how this quest for understanding is reflected in the ÐÓ°ÉÔ­´´â€™s science, its people and the ecosystem of the ÐÓ°ÉÔ­´´ ÐÓ°ÉÔ­´´ Campus, and looks ahead to the next four years’ work.

18/12/2023

From tiny worms to big discoveries

This feature was written by Becky Allen for the 2021-2022 Review.

Dr Della David reflects on her first 12 months at the ÐÓ°ÉÔ­´´, reveals the roots of her own scientific curiosity, and explains how a tiny, transparent, short-lived worm is enabling her to discover new ways of promoting healthy ageing.

18/12/2023

Time flies

This feature was written by Becky Allen for the 2021-2022 Review.

Joining a new organisation and building your research team during a pandemic isn’t ideal but new group leader Dr Ian McGough is pleased he’s found his niche, and gorgeous trail running routes, alongside a very warm welcome.

29/11/2021

A remarkable partnership

This feature was written by Becky Allen for the Annual ÐÓ°ÉÔ­´´ Report 2019-2020.

Great science depends on teamwork, yet genuine partnerships are rare, especially those which sustain success over decades. Dr Len Stephens and Dr Phill Hawkins, both group leaders in the ÐÓ°ÉÔ­´´â€™s Signalling programme, have worked together for more than 30 years. Here, they reflect on their research, their relationship – and their distinctly different approaches to fishing.

29/11/2021

Back to basics

This feature was written by Becky Allen for the Annual ÐÓ°ÉÔ­´´ Report 2019-2020.

Setting up a new group is exciting and daunting. Two group leaders who joined the Signalling programme in 2019 – Dr Hayley Sharpe and Dr Rahul Samant – talk about their research and the supportive, collaborative and open environment that they say marks out the ÐÓ°ÉÔ­´´.

05/08/2019

Welcome to the lipidome

This feature was written by Becky Allen for the Annual ÐÓ°ÉÔ­´´ Report 2018

Once neglected as too dull to study and too sticky to work with, lipids are at last stepping out of the shadows. ÐÓ°ÉÔ­´´ Director Michael Wakelam and lipidomics facility manager Andrea Lopez-Clavijo explain the challenges of working with these cellular Cinderellas and share their excitement of research in a field that’s finally giving up its secrets.

01/07/2018

Making the Most of Signalling ÐÓ°ÉÔ­´´

This feature was written by Becky Allen for the Annual ÐÓ°ÉÔ­´´ Report 2017

Bringing together the ÐÓ°ÉÔ­´´â€™s researchers with scientists in the 60 companies on the ÐÓ°ÉÔ­´´ ÐÓ°ÉÔ­´´ Campus is helping turn innovative ideas into new benefits for human health – fast. Over the past two years, members of the Signalling research programme have transformed a conversation over coffee into a collaboration that could deliver new ways of treating some of the most intractable human cancers.

01/05/2017

The quiet pathway

This feature was written by Becky Allen for the Annual ÐÓ°ÉÔ­´´ Report 2016

For many years regarded as merely a cell biological process, autophagy is now implicated in many diseases. Thanks to progress made in the Signalling research programme this year autophagy – the mechanism cells use to recycle unwanted or damaged components to create molecules they need – is now understood in greater detail than ever before. We find out how research at the ÐÓ°ÉÔ­´´ could harness autophagy to help us age more healthily.