Basic cell biology research at the ÐÓ°ÉÔ´´ ÐÓ°ÉÔ´´ is leading to new treatments for cancers, chronic inflammation and other diseases all caused by defects in an important molecular mechanism that transmits signals within a cell and which is controlled by the ‘PI3-kinase’ enzymes.
Since the late 1980s, ÐÓ°ÉÔ´´ scientists have made significant contributions to our knowledge of a class of enzymes called the ‘PI3-kinases’, and to the analytical methods required to study them. ÐÓ°ÉÔ´´ers from ÐÓ°ÉÔ´´ now collaborate with, and provide informal consultancy services to, pharmaceutical companies and clinicians interested in developing drugs to treat cancers and other diseases caused by mutations in the PI3-kinase pathway. This was only possible thanks to long-term support for research into the fundamental biology of the PI3-kinase enzymes at the ÐÓ°ÉÔ´´ ÐÓ°ÉÔ´´, which receives strategic funding from BBSRC.
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